The papers summarize research in human disease modelling being carried out in connection to several national and European projects. In the most recent publication, the generation of an AD model based on iPSC-cells and gene editing of the PSEN1 gene is described, a work that has been done in the framework of the nationally funded BrainStem project. In the second publication, the work on generating a complete iPSC-based APOE model is described. Bioneer has mainly run this development together with Janssen, a leading pharmaceutical company, through the comprehensive IMI project called EBiSC. In the third and last publication, Bioneer has within the national project called NeuroStem contributed to another AD model focusing on the APP gene.
For more information about disease modelling at Bioneer, please contact R&D Manager Bjørn Holst via email or call +45 45 160 444.
Fredriksen et al. (Feb 2019). Generation of two isogenic iPSC lines with either a heterozygous or a homozygous E280A mutation in the PSEN1 gene. LINK
Schmid et al. (Jan 2019) Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line. LINK
Fredriksen et al. (Jan 2019) Generation of two iPSC lines with either a heterozygous V717I or a heterozygous KM670/671NL mutation in the APP gene. LINK