Induced pluripotent stem cells (iPSCs) have revolutionised the field of human in vitro modelling, providing an unparalleled tool for studying cell types that are not readily accessible from human donors. This is particularly significant in the context of neurodegenerative disease research for disease such as Alzheimer’s and Parkinson’s disease, where precise and reliable models are essential for understanding complex brain functions and diseases.

At Bioneer, we specialise in generating neurons through both traditional growth factor-mediated differentiation and innovative accelerated differentiation techniques using inducible transcription factors such as NGN2. Our expertise extends across various neuronal cell types, including:

• Glutamatergic/Excitatory Neurons
• GABAergic/Inhibitory Neurons
• Dopaminergic Neurons
• Sensory Neurons

In addition to these neuronal types, we also develop critical glial cell types, which are essential for brain health and function:

• Microglia
• Astrocytes

To further enhance the physiological relevance of our models, Bioneer has developed advanced co-culture systems that combine these neuronal and glial cell types. These co-cultures offer a more accurate representation of the human brain’s cellular environment, making them invaluable for studying complex neurological processes and for drug discovery.

We offer the flexibility to develop models using our extensive collection of iPSCs that carry disease-relevant genotypes in genes such as APOE, TREM2, CD33, PSEN1, PGRN, and SNCA. Additionally, we can create unique models tailored to your research needs through our CRISPR gene editing services.

Bioneer’s cutting-edge neuronal differentiation and co-culture capabilities are designed to support your research at every stage. Whether you’re exploring new therapeutic strategies or conducting basic neuroscience research, our lsolutions can provide the insights you need. Contact us today to learn more about how we can assist with your next project.