3D Cancer Assays
– With xCELLigence® RTCA eSight
Capture precise, real-time data across defined time intervals.
BioSPHEER™ is our in vitro 3D cancer platform — offering tailored tumor models that simulate the complexity and cellular diversity of solid tumors as they appear in the human body.
Our new assays combine these 3D cancer models with the eSight® system for real-time cell analysis (RTCA).
This allows you to run long-term experiments and efficiently generate high-quality, decision-ready imaging data.
With the assays, you get:
- Continuous data without disturbing the cells
- Real-time views of immune-cell-tumor interactions
- Quantitative readouts of activation, proliferation, apoptosis and cytotoxicity
- Confident evaluation of therapeutic efficacy
- Clear insights to uncover mechanisms of action
Read more about our 3D cancer model, BioSPHEER™
A new generation of cancer assays for drug screening and characterization
Our real-time cancer assays provide unprecedented insights into effects and properties of anti-cancer drug modalities.
Used by drug developers to:
- Monitor drug and cell-mediated cytotoxic and cytostatic effects in real time
- Investigate tumour induced immune cell differentiation and function in 3D
- Investigate drug penetrance and distribution in a 3D tumour context
- Directly and with high sensitivity measure immune cell-mediated killing of cancer cells
From snapshots to continuous insights into treatment effects
Traditional endpoint assays capture only a single snapshot at the end of an experiment. They disturb cells during measurement and fail to capture critical dynamics that occur in between.
Our 3D xCELLigence® RTCA eSight cancer assays continuously monitor cellular behavior, capturing how tumor and immune cells grow, interact, and respond to treatment in real time.
They deliver a holistic picture of treatment effects, revealing mechanisms that endpoint assays can’t capture and enabling more confident decision-making.
This means we can see exactly when to stop an experiment, saving time and resources, while using each study as a pilot to design smarter, more efficient experiments.
Comprehensive readouts from a single experiment
From a single uninterrupted experiment, you can track multiple aspects of cellular response:
Proliferation
– Monitor tumor and immune cell growth and reveal how therapies affect expansion and activation.
Cytotoxicity
– Quantify tumor cell killing and track loss of viability in 3D spheroids.
Apoptosis
– Follow programmed cell death events continuously to assess therapeutic efficacy and timing.
Immune cell clustering and infiltration
– Visualize how T cells infiltrate, cluster, and engage with tumor spheroids.
For further information please contact Business Developer Philip Carlsen on pca@bioneer.dk or +4521679734
For further information please contact Senior Business Developer Sarah Rank Rønnow on srr@bioneer.dk or +4526291248
Contact us for a free consultation
Interested in learning how the assays could support your project or pipeline?
We offer a free initial consultation to explore your needs.
