We can assist in both simple or complex studies with few or several parameters, one or more cancer drug candidates of interest, in a multicellular milieu. We can test candidates alone or in combination with relevant commercially-available reference drugs.

We have a strong expertise in immune-oncology and can assist companies with a broad range of in vitro models and assays. These includes:

• Immune suppressor assays including T-regs
• Dendritic / T-cell model including immune suppressive DCs, so-called DC10s
• Simulated tumor microenvironment by using Tumor-conditioned Media (TCM)
• Different immortalized cancer cell models
• Different cell co-cultures mimicking cancer micro environments
• Detection of tumor cells in blood
• Checkpoint inhibitor blockade
• Reprogramming and genome editing of immune cells [LINK Specialized Services – Gene Edting & Reprogramming]
• Cytokine release assays
• Generation of cancer-specific cell lines
• Advanced biomarker analysis from single cells to complex tissue samples [LINK to Specialized Services – Molecular Histology and Detection.

Above is a selection of model and assays in the immuno-oncology field that we can perform. Depending on individual project and client needs, we will tailor and adapt the study set-up to fit the specific purpose.

For further information, please contact Department Head Bjørn Holst by phone +45 45160444 or email.