Postdoctoral researcher in CHO Cell Line Engineering and development

If you are curious about the biopharmaceutical industry and want to establish your career as a researcher in the field with both an academic and industrial angle, this is your opportunity. The National Biologics Facility (NBF) at DTU Bioengineering in collaboration with Bioneer A/S are seeking a highly motivated postdoctoral researcher with an interest in engineering and development of Chinese hamster ovary (CHO) cells for production of biopharmaceuticals.

You will join a highly dynamic and collaborative team of researchers and will spend half of your time at NBF in the Mammalian cell line engineering group headed by Ass. Prof. Lise Marie Grav and the other half of your time with the team of Upstream Development of Mammalian cells at Bioneer A/S headed by Alexandra Baer. You will join a larger research effort that focuses on optimizing and speeding up the development process of CHO cells for improved production of complex therapeutic proteins.

NBF is part of the Technical University of Denmark and provides an excellent research environment with state-of-the-art facilities and advanced technologies with special emphasis on cell factory engineering and system biology technologies. Bioneer A/S is an innovative research-based not-for-profit organization with more than 35 years of experience in converting scientific achievements to industrial applications and services for the biotech and pharma industry.

Responsibilities and qualifications
Your overall focus will be on developing novel tools and strategies that reduce the development time of CHO production cell lines. You will be working with genome editing and other synthetic biology tools to make high producing cell lines with predictive performance at an industrial relevant scale. You will be collaborating with scientists at both NBF and Bioneer A/S on a daily basis and take part in their ambition to develop excellent science into industrial attractive solutions for recombinant protein production.

Specific tasks include (not limited to):

  • Design and construct superior CHO cell lines using CRISPR technologies
  • Cultivate and characterize improved CHO cell lines in small and large scale
  • Study clonal variation and basic biology of therapeutic protein production
  • Collaborate with the other researchers in the teams at NBF and Bioneer A/S
  • Give lectures at courses and/or present your research to the public
  • Write research articles
  • Teach and supervise MSc students during thesis projects

As a formal qualification, you must hold a PhD degree in biotechnology, bioengineering, biochemistry, biology or equivalent.

We are looking for a colleague with previous laboratory experience working with mammalian cells, genome engineering and recombinant protein production. This includes familiarity with methods for cloning of expression vectors, genome editing technologies, and omics data analysis.

As most of our work focus on development of cell lines for optimal therapeutic protein production, a good understanding of cell biology is essential.

Additionally, your CV will demonstrate:

  • Ability to communicate technical information to internal/external audiences at various levels and from various backgrounds
  • Ability to work independently and as part of a team
  • Ability to successfully work on multiple concurrent projects and support collaborations between research teams
  • That you are proactive and thrive with solving problems
  • That you enjoy sharing knowledge and your experience with others

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The period of employment is 2 years.

You can read more about career paths at DTU here.

Further information
Further information may be obtained from Ass. Prof. Lise Marie Grav (lgrav@dtu.dk) and Alexandra Baer (aba@bioneer.dk).

You can read more about DTU Bioengineering at https://www.bioengineering.dtu.dk/english

You can read more about Bioneer A/S at https://bioneer.dk/

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.

Application procedure
Your complete online application must be submitted no later than 16 September 2021 (Danish time).

Applications must be submitted as one PDF file containing all materials to be given consideration.

To apply, please click here, fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

  • Application (cover letter)
  • CV
  • Academic Diplomas (MSc/PhD)
  • List of publications

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science industry and point towards innovation, new businesses, and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 300 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.

Bioneer is an innovative research-based not-for-profit organization operating as a strategic research partner to biotech and pharmaceutical companies and collaborators engaged in discovery and early development of biologics and small molecule therapeutics. We excel in delivering customized research service solutions for protein manufacturing, advanced disease modelling and early drug development globally while we continuously aim to improve our research solutions at the interface between biology and other sciences.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,900 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

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